白癜风有治好的吗 https://m-mip.39.net/nk/mipso_7157873.htmlEffectsofAntibioticPretreatmentofanUlcerativeColitis-DerivedFecalMicrobialCommunityontheIntegrationofTherapeuticBacteriaInVitro.
对溃疡性结肠炎患者的粪便菌群进行抗生素预处理对体外整合治疗菌的影响
Abstract
Fecalmicrobiotatransplantation(FMT)isaproposedlyusefulstrategyforthetreatmentofgastrointestinal(GI)disordersthroughremediationofthepatientgutmicrobiota.However,itstherapeuticsuccesshasbeenvariable,necessitatingresearchtouncovermechanismsthatimprovepatientresponse.Antibioticpretreatmenthasbeenproposedasonemethodtoenhancethesuccessratebyincreasingnicheavailabilityforintroducedspecies.Severallimitationshinderexploringthishypothesisinclinicalstudies,suchasdeleterioussideeffectsandthedevelopmentofantimicrobialresistanceinpatients.Thus,thepurposeofthisstudywastoevaluatetheuseofaninvitro,bioreactor-based,colonicecosystemmodelasaformofpreclinicaltestingbydetermininghowpretreatmentwiththeantibioticrifaximininfluencedengraftmentofbacterialstrainssourcedfromahealthydonorintoanulcerativecolitis-deriveddefinedmicrobial
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