InflammatorybiomarkersresponsetotwodosagesofvitaminDsupplementationinpatientswithulcerativecolitis:Arandomized,double-blind,placebo-controlledpilotstudy.
探讨溃疡性结肠炎患者接受两种剂量的维生素D补剂对炎性生物标志物的影响：一项随机双盲安慰剂对照的前瞻试验
Abstract
ThisstudywasdesignedtodeterminetheeffectsoftwodosagesofvitaminDsupplementationoninflammatorybiomarkersinpatientswithulcerativecolitis(UC).FiftymildtomoderateactiveUCpatientswererandomlyassignedtoconsumeeitherorIU/dayvitaminDfor12weeks.Inflammatorybiomarkers,diseaseactivity,qualityoflife,anthropometricindices,dietaryintakes,andphysicalactivityweremeasuredatthebeginningandtheendofthestudy.Serumlevelofhs-CRPdecreasedinbothgroupsattheendofstudy,butthechangeswerenotsignificantlydifferentwithinandbetweengroups.SerumlevelofTNF-αinthehighdosegroupwasreducedattheendofthestudynon-significantly(P-value=0.).
Inthelowdosegroup,asignificantincreaseinserumTNF-αconcentrationwasobserved(p≤0.).ThechangesinserumTNF-αweresignificantlydifferentbetweentwogroups(p=0.);however,afteradjustingfortheeffectofconfounders,thesignificanceeffectwasdisappeared(p=0.).ActivityofNF-κBincreasedinbothgroupswhilethisincreasewassignificantinthelowdosegroup
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